ArticleInternational journal of molecular sciences2026
Circulating miR-16 as an Early Biomarker of Subclinical Myocardial Strain Impairment in Pediatric Primary Hypertension.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- MicroRNAs in Pediatric Primary Hypertension: Promising Biomarkers or Context-Dependent Regulators?-A Narrative Review.Biomolecules · 2026Review
- ATHENA Study - The Role of Circulating Plasma MicroRNAs in Paediatric Patients with Untreated Primary Hypertension: Baseline Expression and Exercise-Induced Changes.Kidney & blood pressure research · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The role of circulating microRNAs in the pathophysiology of cardiac remodeling in primary hypertension (PH) remains incompletely understood. Left ventricular global longitudinal strain (LV GLS) is a sensitive marker of subclinical systolic dysfunction and can be used to monitor early cardiac involvement in cardiovascular and renal diseases. To the best of our knowledge, this is the first study to demonstrate an association between circulating miR-16 and LV GLS in children. The study aimed to evaluate the expression levels of miR-16-5p, -21-5p, -27a-3p, -27b-3p, -133a-3p, and -145-5p in untreated children with PH and examine their associations with LV GLS. 50 children with PH and 57 normotensive controls were evaluated for circulating microRNA expression levels and echocardiographic parameters, including LV GLS. Comprehensive anthropometric, biochemical, blood pressure, and arterial indices were also assessed. Among the analyzed microRNAs, miR-16-5p exhibited a positive association with LV GLS (R = 0.305,
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.