Evidence map›Paper›PMID 41898677›Full record

ArticleInternational journal of molecular sciences2026

Genetic Regulation of Monocyte MicroRNAs and Their Implication in Musculoskeletal Diseases: A Cross-Ancestry Expression Quantitative Trait Loci and Imputation Study.

Yong Liu, Kuan-Jui Su, Yun Gong, Bo Tian, Anqi Liu, Zhe Luo, Qing Tian, Chuan Qiu, Hui Shen, Hong-Mei Xiao and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yong LiuCenter for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Changsha 410031, China.ORCID 0000-0001-9360-1304
Kuan-Jui SuTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-5163-9774
Yun GongTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0009-0001-4049-5736
Bo TianCenter for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Changsha 410031, China.
Anqi LiuTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-5829-2371
Zhe LuoTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-6495-408X
Qing TianTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Chuan QiuTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Hui ShenTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Hong-Mei XiaoInstitute of Reproductive & Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410000, China.
Hong-Wen DengTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-0387-8818

Funding

Tulane COBRE for Clinical and Translational Research in Cardiometabolic DiseasesP20GM109036 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.2M
Trans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.1M
Intensive Lifestyle Intervention, Metabolomics, and Risk of Frailty Fracture in Overweight or Obese Patients with Type 2 DiabetesR01AG068232 · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2025 to 2025
$589k
NIA NIH HHS R01 AG068232NIA NIH HHS U19 AG055373NIGMS NIH HHS P20 GM109036The National Institutes of Health (NIH) P20GM109036, U19AG055373, R01AG061917, and R01AG068232
6 · The paper itself

Abstract

This study investigated the genetic regulation of microRNA (miRNA) expression in monocytes and its potential role in musculoskeletal diseases. We mapped expression quantitative trait loci (eQTLs) for miRNAs using data from 281 Caucasian (CAU) and 170 African American (AA) individuals, constructed ancestry-specific models to impute miRNA expression from genotype data, and applied these models to test associations with osteoporosis and sarcopenia. Analysis identified 468 and 2653 independent eQTLs for 61 miRNAs in CAU and 25 in AA, respectively, the majority of which were ancestry-specific. Association analyses identified 22 and 26 miRNAs associated with osteoporosis and sarcopenia, respectively, in the CAU population; corresponding findings in the African American population were 26 and 14 miRNAs. Analysis of their target genes revealed 1238 and 741 genes that were nominally associated with osteoporosis and sarcopenia in CAU; with 524 genes associated with osteoporosis and 891 associated with sarcopenia in AA. Functional enrichment analysis indicated that the target genes of the identified miRNAs are involved in disease-relevant biological processes-cell migration and motility in osteoporosis, and immune/cytokine responses in sarcopenia. This work provides insights into the genetic architecture of miRNA expression and implicates monocyte miRNAs in musculoskeletal diseases, underscoring the importance of including diverse ancestral backgrounds in genomic studies.

Indexed as

Gene Expression RegulationMicroRNAsMonocytesMusculoskeletal DiseasesQuantitative Trait LociBlack or African AmericanGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansOsteoporosisPolymorphism, Single NucleotideSarcopeniaWhite PeopleMicroRNAseQTLimputation modelmicroRNAmonocytemusculoskeletal diseases

Identifiers

PMID41898677
PMCPMC13026450

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.