Evidence map›Paper›PMID 41898737›Full record

ArticleInternational journal of molecular sciences2026

Temporal Dynamics of Endothelium After Radiation Injury Reveal a Transient Pro-Angiogenic Capillary Subpopulation Associated with Skin Repair.

Xuejiao Ren, Yating Cai, Chengming Gao, Yifei Qiu, Xia Wang, Huiyang Song, Yansheng Zhu, Xiaoqi Zhou, Jianhao Li, Gangqiao Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuejiao RenCollaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Yating CaiCollaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Chengming GaoState Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing 102206, China.
Yifei QiuState Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing 102206, China.
Xia WangState Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing 102206, China.
Huiyang SongState Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing 102206, China.
Yansheng ZhuCollege of Life Sciences, Anhui Medical University, Hefei 230032, China.
Xiaoqi ZhouCollege of Life Science, Hebei University, Baoding 071002, China.
Jianhao LiHengyang Medical College, University of South China, Hengyang 421001, China.
Gangqiao ZhouCollaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Pengbo CaoState Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing 102206, China.

Funding

National Key R&D Program of China No. 2025YFC3513102National Natural Science Foundation of China No. 82172707National Natural Science Foundation of China No. 82573493
6 · The paper itself

Abstract

Ionizing radiation (IR) causes severe vascular damage, yet the dynamic functional states and regulatory mechanisms of vascular endothelial cells (VECs) after irradiation remain poorly understood. To elucidate the underlying processes, we analyzed single-cell RNA sequencing data from mouse dorsal skin collected at multiple post-irradiation (p.i.) time points using trajectory inference, pathway enrichment, transcription factor activity inference, and cell-cell communication analyses. Our results showed that VECs exhibited marked temporal dynamics after irradiation, transitioning from early-stage stress responses to middle-stage angiogenic remodeling and late-stage restoration of homeostasis. A transient

Indexed as

AngiogenesisCapillariesEndothelial CellsEndothelium, VascularNeovascularization, PhysiologicSkinWound HealingAnimalsKeratinocytesMiceSignal Transductionionizing radiationscRNA-seqskinSp1vascular endothelial cells

Identifiers

PMID41898737
PMCPMC13027251

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.