Evidence map›Paper›PMID 41898761›Full record

SynthesisInternational journal of molecular sciences2026

Investigating the Inflammatory Link Between Vitamin D and Hidradenitis Suppurativa: A Systematic Review and Causal Inference Analysis.

Jasmine Spiteri, Laura Grech, Dillon Mintoff, Nikolai P Pace

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jasmine SpiteriCentre for Molecular Medicine & Biobanking, University of Malta, MSD 2080 Msida, Malta.
Laura GrechCentre for Molecular Medicine & Biobanking, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0002-1661-7158
Dillon MintoffDepartment of Pathology, Faculty of Medicine & Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0003-3705-0119
Nikolai P PaceCentre for Molecular Medicine & Biobanking, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0002-7332-874X

Funding

University of Malta HS-FUNOMICS
6 · The paper itself

Abstract

An inverse correlation between serum vitamin D levels and hidradenitis suppurativa (HS) severity is frequently reported, yet the causal nature and direction of this association remain unresolved. A systematic review was conducted following PRISMA guidelines, identifying 12 relevant studies. A two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW) method was subsequently performed using genetic instruments for vitamin D from the UK Biobank (

Indexed as

Hidradenitis SuppurativaInflammationVitamin DVitamin D DeficiencyHumansMendelian Randomization AnalysisVitamin Dhidradenitis suppurativaimmune modulationinflammatory markerMendelian randomizationvitamin D

Identifiers

PMID41898761
PMCPMC13026541

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.