Evidence mapPaperPMID 41899251Full record

ReviewJournal of clinical medicine2026

Revisiting the Genetics of Hypertrophic Cardiomyopathy: From Sarcomeres to Polygenic Modulation and Clinical Translation.

Maria Cristina Carella, Marco Maria Dicorato, Paolo Basile, Ilaria Dentamaro, Daniela Santoro, Eugenio Carulli, Michele Davide Latorre, Eduardo Urgesi, Francesco Monitillo, Nicoletta Resta and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cardiovascular magnetic resonance-derived left atrial parameters for assessing diastolic dysfunction and prognosis in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Cristina CarellaUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Marco Maria DicoratoUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0008-4865-2522
Paolo BasileUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Ilaria DentamaroUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Daniela SantoroUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Eugenio CarulliUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-1725-0279
Michele Davide LatorreUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Eduardo UrgesiUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0458-1469
Francesco MonitilloUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Nicoletta RestaMedical Genetics Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", University Hospital Consortium, Polyclinic of Bari, 70124 Bari, Italy.ORCID 0000-0001-8640-5532
Gianluca PontoneDepartment of Perioperative Cardiology and Cardiovascular Imaging, IRCCS Centro Cardiologico Monzino, 20138 Milan, Italy.ORCID 0000-0002-1339-6679
Marco Matteo CicconeUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.
Andrea Igoren GuaricciUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7133-4401
Cinzia ForleoUniversity Cardiology Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-9452-4037

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy, represents a paradigmatic condition for precision cardiovascular medicine. Once regarded as a monogenic autosomal dominant disorder driven by rare sarcomeric variants, HCM is now recognized as a genetically complex disease characterized by incomplete penetrance, variable expressivity, and heterogeneous clinical trajectories. This review summarizes current evidence on the evolving genetic architecture of HCM, emphasizing the predominant role of definitively validated sarcomeric genes, particularly

Indexed as

cardiogeneticsdeep intronic variantsgenetic modifiershypertrophic cardiomyopathyincomplete penetranceMYBPC3MYH7phenocopiespolygenic risk scoreprecision cardiologysarcomeric genes

Identifiers

PMID41899251
PMCPMC13027194

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.