ReviewCancers2026
Diagnostic Utility of Neutrophil-to-Lymphocyte Ratio in Differentiating Benign and Malignant Ovarian Masses: A Systematic Review.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesGiven its cost-effectiveness and availability, NLR could play a pivotal role in refining the diagnostic process. We aimed to evaluate whether NLR can serve as a useful marker to differentiate between benign and malignant ovarian masses, synthesizing available evidence to provide a comprehensive assessment of its diagnostic value.
methodsA comprehensive search was conducted across the following electronic databases: PubMed, Europe PMC, and SCOPUS on 4 January 2026. For inclusion, studies were required to report on the use of NLR as a biomarker for differentiating ovarian masses, involve human participants with preoperative measurements of these ratios, and provide data on diagnostic accuracy, such as sensitivity, specificity, or receiver operating characteristic (ROC) curves. Both retrospective and prospective observational studies were considered.
resultsThis systematic review incorporated data from 3675 patients across ten studies. The meta-analysis revealed that malignant masses exhibited a significantly elevated mean NLR (HR -0.80 [95% CI: -1.17 to -0.42]), but found no statistically significant correlation (OR 1.49 [95% CI: 0.67 to 3.30]). NLR had moderate diagnostic performance with an AUC of 0.66 (95% CI: 0.62-0.69).
conclusionsWhile malignant ovarian masses are associated with a significantly higher mean NLR, the overall diagnostic performance of NLR remains moderate, suggesting limited utility in distinguishing between benign and malignant tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.