Evidence map›Paper›PMID 41900474›Full record

ArticleMicroorganisms2026

Enhancing Synthesis Efficiency in Microbial 1,5-Pentanediol Production Through Transcriptomics-Informed Metabolic Engineering of

Hongyu Deng, Fei Meng, Yihao Sun, Yang Song, Chunhui Zhao, Xiaonan Wang, Yan Zhang, Ruiming Wang, Ning Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongyu DengCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Fei MengCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Yihao SunState Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Science), Jinan 250353, China.
Yang SongState Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Science), Jinan 250353, China.ORCID 0000-0003-3884-3276
Chunhui ZhaoState Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Science), Jinan 250353, China.
Xiaonan WangCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Yan ZhangState Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Science), Jinan 250353, China.
Ruiming WangState Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Science), Jinan 250353, China.
Ning ChenCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.

Funding

the national key research and development program of china 2023YFD1300702
6 · The paper itself

Abstract

The microbial production of 1,5-pentanediol (1,5-PDO), a versatile platform chemical with extensive industrial applications, remains limited by suboptimal fermentation titers and incomplete understanding of metabolic bottlenecks. To address these challenges, this study employed comparative transcriptomics to systematically identify novel genetic targets capable of enhancing 1,5-PDO biosynthesis in engineered

Indexed as

1,5-pentanediolCRISPR/Cas9Escherichia colimetabolic engineeringtranscriptomic analysis

Identifiers

PMID41900474
PMCPMC13028967

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.