Evidence map›Paper›PMID 41901017›Full record

ArticleLife (Basel, Switzerland)2026

Effects of the Uncoupling Protein 1 (UCP1) A-3826G Polymorphism on Taste Preferences in Healthy Young Japanese Adults.

Toshishige Kokubun, Tada-Aki Kudo, Kanako Tominami, Hirotaka Ishigaki, Ayumu Matsushita, Satoshi Izumi, Takakuni Tanaka, Kotoku Kawaguchi, Yohei Hayashi, Hajime Sato and 5 more

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Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toshishige KokubunDivision for Globalization Initiative, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Tada-Aki KudoDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.ORCID 0000-0003-1666-9588
Kanako TominamiDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.ORCID 0000-0003-4342-6979
Hirotaka IshigakiDivision for Globalization Initiative, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Ayumu MatsushitaDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Satoshi IzumiDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Takakuni TanakaDivision for Globalization Initiative, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Kotoku KawaguchiDivision of Pharmacology, Meikai University School of Dentistry, Sakado 350-0283, Japan.
Yohei HayashiDepartment of Oral Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.
Hajime SatoDivision of Pharmacology, Meikai University School of Dentistry, Sakado 350-0283, Japan.ORCID 0000-0003-1066-0769
Naoki ShojiSchool of Food Industrial Sciences, Miyagi University, Sendai 982-0215, Japan.
Keiko Gengyo-AndoDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Kazunori AdachiDivision of Pharmacology, Meikai University School of Dentistry, Sakado 350-0283, Japan.
Junichi NakaiDivision of Oral Physiology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Guang HongDivision for Globalization Initiative, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.ORCID 0000-0002-6620-1302

Funding

Tohoku University and Miyagi University 3
6 · The paper itself

Abstract

backgroundThe

methodsWe examined associations between the A-3826G polymorphism and food preferences in healthy young Japanese adults (50 males, 48 females). Preferences for high-fat and basic-taste foods were assessed using a self-administered questionnaire, with sweet foods classified as low- or high-fat. Genotypes (AA, AG, GG) were analyzed using a two-way mixed-design ANOVA to evaluate genotype × fat level interactions.

resultsPreference scores for basic tastes did not differ significantly among genotypes in either sex (except for sour taste in males). In males, no significant genotype × fat level interaction was observed, although AA carriers preferred high-fat to low-fat sweet foods (

conclusionsThese findings indicate that the UCP1 A-3826G polymorphism may modulate preference for high-fat sweet foods in a sex-dependent manner, suggesting a link between thermogenic genetic variation and dietary fat preference relevant to obesity prevention.

Indexed as

brown adipose tissueenergy metabolismfood preferenceshigh-fat sweet foodsobesitysingle-nucleotide polymorphism (SNP)UCP1

Identifiers

PMID41901017
PMCPMC13028302

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.