Evidence map›Paper›PMID 41901052›Full record

ArticleNutrients2026

Brewed Coffee and Its Components Act Through Orphan Nuclear Receptor 4A1 (NR4A1).

Amanuel Hailemariam, Srijana Upadhyay, Arafat Rahman Oany, Wai Ning Tiffany Tsui, Vinod Srivastava, Gargi Sivaram, Kelly Churion, Robert S Chapkin, Laurie A Davidson, Shoshana Eitan and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanuel HailemariamDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-8068-3619
Srijana UpadhyayDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
Arafat Rahman OanyDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-2228-457X
Wai Ning Tiffany TsuiDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0004-0763-7458
Vinod SrivastavaDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77845, USA.
Gargi SivaramDepartment of Biochemistry and Biophysics, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-4278-7019
Kelly ChurionInstitute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX 77030, USA.ORCID 0000-0002-4346-7562
Robert S ChapkinDepartment of Nutrition, Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6515-3898
Laurie A DavidsonDepartment of Nutrition, Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-4159-4680
Shoshana EitanDepartment of Psychological and Brain Sciences, Behavioral and Cellular Neuroscience, Texas A&M University, College Station, TX 77843, USA.
James J CaiDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77845, USA.ORCID 0000-0002-8081-6725
Roger NortonDepartment of Agricultural Economics, Texas A&M's Center for Coffee Research and Education, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0003-9775-9987
Stephen SafeDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2115-3060

Funding

CPRIT funded core facility RP250505Institute of Advancing Health Through Agriculture NATexas A&M AgriLife NA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CoffeeNuclear Receptor Subfamily 4, Group A, Member 1PolyphenolsAnimalsCell Line, TumorHumansMiceMolecular Docking SimulationProtein BindingRAW 264.7 CellsCoffeeNR4A1 protein, humanNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Polyphenolscoffee extractsNR4A1polyphenolicsreceptor binding

Identifiers

PMID41901052
PMCPMC13029766

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.