Evidence map›Paper›PMID 41901096›Full record

ArticleNutrients2026

Curcumin-Loaded Lactoferrin/Pectin Core-Shell Structured Microgel Nanoparticles: Dual Regulatory Effects in Alleviating Inflammatory Bowel Disease.

Ming-Yu Jin, Sai-Yin Yu, Er-Feng Wang, Henan Zhang, Jing-Yi Xu, Chen Wang, Long-Qing Li, Jing-Kun Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming-Yu JinDongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Sai-Yin YuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Er-Feng WangDongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Henan ZhangInstitute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai 201403, China.
Jing-Yi XuDongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Chen WangCollege of Food Science, South China Agricultural University, Guangzhou 510642, China.
Long-Qing LiDongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Jing-Kun YanDongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.ORCID 0000-0001-9547-3772

Funding

Guangdong Province's Innovation and Enhancement Initiative for Universities Project 231104007National Natural Science Foundation of China 32402027
6 · The paper itself

Abstract

backgroundCurcumin (Cur) has therapeutic potential for inflammatory bowel disease (IBD) but is limited by its poor bioavailability.

methodsThis study demonstrated that Cur-loaded core-shell structured microgel nanoparticles (LF/CP-Cur MN), fabricated through electrostatic complexation between lactoferrin and citrus pectin, followed by Ca

resultsThese nanoparticles effectively reduced the bitterness and astringency of curcumin while prolonging its release time. In an IBD mouse model, LF/CP-Cur MN treatment mitigated symptoms and inflammation of IBD, and restored intestinal barrier integrity. Crucially, compared with free Cur, the LF/CP-Cur MN enhanced colon-targeted accumulation of Cur and favorably modulated the gut microbiota by increasing beneficial genera like

conclusionsThese findings highlight the potential of the LF/CP-Cur MN to improve Cur bioaccessibility and exert dual functional roles in modulating gut microbiota and alleviating inflammation, thus offering a promising dietary strategy for the management of IBD.

Indexed as

CurcuminInflammatory Bowel DiseasesLactoferrinMicrogelsNanoparticlesPectinsAnimalsBiological AvailabilityColonDisease Models, AnimalHumansIntestinal Barrier FunctionMiceMice, Inbred C57BLCurcuminLactoferrinMicrogelsPectinscore–shell microgel nanoparticlescurcumindual regulatory effectsinflammatory bowel disease

Identifiers

PMID41901096
PMCPMC13029212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.