ArticleNutrients2026
Association Between Dietary Fiber Intake and Inflammatory Biomarkers in U.S. Adults: A Cross-Sectional Analysis of the Pre-COVID-19 National Health and Nutrition Examination Survey 2017-2018.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesDietary fiber has been associated with lower levels of inflammatory biomarkers, but nationally representative evidence using recent U.S. data remains limited. We evaluated the association between dietary fiber intake and inflammatory biomarkers in U.S. adults using the National Health and Nutrition Examination Survey (NHANES) 2017-2018, the last fully completed cycle before the COVID-19 pandemic, providing a pre-pandemic benchmark for future comparisons.
methodsWe analyzed 3570 adults (≥20 years) from NHANES 2017-2018 with complete dietary and biomarker data. Fiber intake was averaged from two 24 h recalls. Outcomes included serum high-sensitivity C-reactive protein (hs-CRP; primary outcome), white blood cell count (WBC), and neutrophil count. Survey-weighted regression models adjusted for demographic, socioeconomic, lifestyle, clinical, and dietary covariates. Associations were examined continuously (per 5 g/day fiber), by quartiles, and with restricted cubic splines. Sensitivity analyses excluded participants with cardiometabolic conditions or modified covariate sets.
resultsEach 5 g/day higher fiber intake was associated with 4-7% lower hs-CRP (
conclusionsHigher dietary fiber intake was independently associated with a more favorable inflammatory biomarker profile (hs-CRP, WBC, and neutrophils) in U.S. adults, providing a pre-pandemic benchmark for future comparisons. Longitudinal and interventional studies are needed to clarify temporality and causality.
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