Evidence mapPaperPMID 41901151Full record

ReviewNutrients2026

Dietary and Nutritional Strategies for Patients with Glioma: A Narrative Review of Treatment, Recovery, Immune Support, and Microbiota Modulation.

George B H Green, Alexis N Cox-Holmes, Jonathan T Flowers, Michael B Williams, Anna Claire E Potier, Jeri L Brandom, Stephen A Watts, Raymond Luke, Jennifer S Yu, Braden C McFarland

Abstract readReview
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

George B H GreenDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6389-4919
Alexis N Cox-HolmesDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-8203-2801
Jonathan T FlowersDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michael B WilliamsDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Anna Claire E PotierDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jeri L BrandomDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Stephen A WattsDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Raymond LukeDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY 10065, USA.
Jennifer S YuDepartment of Radiation Oncology, Department of Cancer Biology, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-0244-4014
Braden C McFarlandDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Funding

Employing Humanized Microbiome Mice to Understand Immune Activation and Translational Therapeutic Potential in GlioblastomaR01CA270750 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$329k
Training Program in Brain Tumor BiologyT32NS121721 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$167k
NCI NIH HHS R01 CA270750NCI NIH HHS R01CA270750-01A1NINDS NIH HHS T32 NS121721NINDS NIH HHS T32NS121721
6 · The paper itself

Abstract

This narrative review aims to explore the relationship between glioma and nutrition throughout stages of treatment and recovery. Gliomas are aggressive brain tumors that significantly impair quality of life and present treatment challenges. There has been a growing interest regarding the gut-brain axis and the microbiome, particularly their roles in modulating immune function and influencing the response to cancer treatment. This review examines how specific nutritional approaches may assist patients throughout the course of chemotherapy, radiation, immunotherapy, surgical intervention, and the recovery process. It also addresses the potential for integrative nutritional approaches to complement conventional treatment and improve clinical outcomes. Emerging evidence suggests that nutrition may influence immune function, treatment-related side effects, and the tumor microenvironment, in part through effects on the gut microbiota. Nutritional support during therapy has been linked to increased strength, decreased inflammation, and improved treatment tolerance. Dietary patterns may influence gut-brain interactions and systemic immune responses, opening the potential to improve therapeutic outcomes in glioma. In summary, nutrition may represent an important supportive component of glioma care, while microbiota-mediated and metabolic dietary strategies remain areas of active investigation. Further clinical studies are needed to determine whether specific nutritional interventions can improve survival, treatment response, or quality of life in patients with glioma.

Indexed as

Brain NeoplasmsDietGastrointestinal MicrobiomeGliomaNutritional SupportHumansNutritional StatusQuality of LifeTumor Microenvironmentgliomamicrobiotanutritionsurgerywound healing

Identifiers

PMID41901151
PMCPMC13029381

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.