Berberine-Mediated BCRP Inhibition Enhances Systemic Exposure of Rhein: A Study to Unravel the Pharmacokinetic Basis of Synergy in Da-Huang-Xiao-Shi Decoction.

Zhangyao Xu, Hongyu Li, Haoyu Xue, Xiaoge Wang, Tianming Wang, Yuyang Zhou, Jifeng Gu, Rong Shi

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhangyao XuScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Hongyu LiScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Haoyu XueScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Xiaoge WangScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Tianming WangDepartment of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Yuyang ZhouScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-9422-2450

Jifeng GuDepartment of Pharmacy, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.

Rong ShiScience and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Funding

Shanghai Municipal Health Commission ZYCC2019019Talent Project established by Chinese Pharmaceutical Association Hospital Pharmacy depart-ment CPA-Z05-ZC-2025-003

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

berberinecholestasisDa-Huang-Xiao-Shi Decoctionrheintransporters

Identifiers

PMID41901337

DOI10.3390/ph19030492

PMCPMC13028883

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.