SynthesisPathogens (Basel, Switzerland)2026
Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.
Beni Jequicene Mussengue Chaúque, Luiza Bernardes Chagas, Thaisla Cristiane Borella da Silva, Denise Leal Dos Santos, Luciano Palmeiro Rodrigues, Lucile da Silva Lins Baía, Manoella Kessler Gomes Rodrigues, Guilherme Brittes Benitez, Thais Lemos Mendes, Hellen Kempfer Philippsen and 5 more
Abstract readSystematic Review
In one paragraphSynthesis in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Beni Jequicene Mussengue ChaúqueMaster's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0002-9440-3227 Luiza Bernardes ChagasFaculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.ORCID 0009-0004-2271-2559 Thaisla Cristiane Borella da SilvaProtozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.
Denise Leal Dos SantosMaster's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Luciano Palmeiro RodriguesMaster's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0002-6888-192X Lucile da Silva Lins BaíaPostgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.
Manoella Kessler Gomes RodriguesSchool of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90610-970, RS, Brazil.
Guilherme Brittes BenitezIndustrial and Systems Engineering Graduate Program, Polytechnic School, Pontifical Catholic University of Parana (PUCPR), Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-1222-4557 Thais Lemos MendesPostgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.
Hellen Kempfer PhilippsenSocio-Environmental and Water Resources Institute, Federal Rural University of the Amazon (UFRA), Belém 66077-830, PA, Brazil.ORCID 0000-0001-8614-394X Luciana Dalla RosaCentral Laboratory for Avian Disease Diagnosis, Department of Preventive Veterinary Medicine, Center for Rural Sciences, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil .
Fabrício Souza CamposLaboratório de Bioinformática & Biotecnologia, Instituto de Ciências Básicas da Saúde, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.ORCID 0000-0002-5948-472X Marilise Brittes RottProtozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.
Régis Adriel ZanettePostgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.ORCID 0000-0003-4432-2231 José Roberto GoldimMaster's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-2127-6594 Funding
Human Resources Training Project to Support the Development of Clinical Research in Brazil 88887.800.657/2022-00
6 · The paper itselfAbstract
Devastating or nearly invariably fatal infections caused by free-living amoebae (FLA), including
Indexed as
AmebiasisAmebicidesAmoebaAntiprotozoal AgentsDrug RepositioningAcanthamoebaAcanthamoeba KeratitisAnimalsHumansAmebicidesAntiprotozoal AgentsAcanthamoeba keratitisdrug repurposinggranulomatous amoebic encephalitisin vitroin vivoprimary amoebic meningoencephalitis
Identifiers
PMID41901747
PMCPMC13028894
What Socratic holds
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