Evidence map›Paper›PMID 41903067›Full record

ArticleApoptosis : an international journal on programmed cell death2026

HSP90 inhibition potentiates oxidant-based antimelanoma action of novel thioquercetin derivatives by compromising AhR/CYP1A1 pathway.

Wojciech Witkowski, Julia Słaby, Maciej Wnuk, Paulina Stec, Piotr Piotrowski, Michał Żebrowski, Martyna Cybularczyk-Cecotka, Anna Deręgowska, Nadezhda Romanchikova, Pawel Zayakin and 4 more

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wojciech Witkowski *Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Julia Słaby *Doctoral School, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland.
Maciej WnukFaculty of Biotechnology, Collegium Medicum, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland.
Paulina StecFaculty of Biotechnology, Collegium Medicum, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland.
Piotr PiotrowskiFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Michał ŻebrowskiFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Martyna Cybularczyk-CecotkaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Anna DeręgowskaFaculty of Biotechnology, Collegium Medicum, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland.
Nadezhda RomanchikovaCancer Biomarker Group, Latvian Biomedical Research and Study Centre, Ratsupites 1, Riga, LV-1067, Latvia.
Pawel ZayakinCancer Biomarker Group, Latvian Biomedical Research and Study Centre, Ratsupites 1, Riga, LV-1067, Latvia.
Aija LinēCancer Biomarker Group, Latvian Biomedical Research and Study Centre, Ratsupites 1, Riga, LV-1067, Latvia.
María MorosInstituto de Nanociencia y Materiales de Aragón, INMA (CSIC-Universidad de Zaragoza), C/Pedro Cerbuna 12, 50009, Zaragoza, Spain.
Grzegorz LitwinienkoFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland. litwin@chem.uw.edu.pl.
Anna LewińskaFaculty of Biotechnology, Collegium Medicum, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland. alewinska@ur.edu.pl.

Funding

Latvijas Zinātnes Padome ES RTD/2023/38MICIU/AEI/https://doi.org/10.13039/501100011033 PCI2023-143448Narodowe Centrum Nauki 2021/43/B/ST4/00840Narodowe Centrum Nauki 2022/04/Y/ST5/00155
6 · The paper itself

Abstract

Quercetin, a plant-derived dietary flavonoid, has multifunctional biological activities, including anticancer action; however, its applications may be restricted due to limited bioavailability. Thus, novel synthetic quercetin derivatives (QDs) with improved properties and/or drug combinations should be designed and tested. In the present study, anticancer activity of fourteen newly synthesized QDs was investigated using four cellular models of melanoma, namely A375, MM370, G-361, and SH-4 cells. Thioquercetins (thioQ, thioQ(OAc)

Indexed as

Antineoplastic AgentsCytochrome P-450 CYP1A1HSP90 Heat-Shock ProteinsMelanomaQuercetinReceptors, Aryl HydrocarbonApoptosisCell Line, TumorHumansOxidative StressSignal TransductionAntineoplastic AgentsCytochrome P-450 CYP1A1HSP90 Heat-Shock ProteinsQuercetinReceptors, Aryl HydrocarbonCytochrome P450HSP90 inhibitionMelanomaOxidative stressThioquercetin

Identifiers

PMID41903067
PMCPMC13032962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.