GIP/GLP-1 & amylin agonists × kidney outcomes

TrialJAMA cardiology2026

Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial.

Steven E Nissen et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 13,165 people · 2026

Not counted

Lowered kidney outcomes

−16%−21% to −10%

24 in 100 instead of 27

Bigger than 4 in 10 on the map

As reported

HR 0.84, 95% CI 0.79–0.90

One number in the abstract

the abstract, start to end

patients (27.4%; hazard ratio [HR], 0.84; 95% CI, 0.79-0.90; P < .001).

← favours treatmentfavours comparator →
could be chance
Kidney outcomes
HR 0.840.79–0.90
GLP-1 receptor agonistsGIP/GLP-1 & amylin agonistsKidney outcomes
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3 papers cite it

2026
this papercites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 41903177