Evidence map›Paper›PMID 41903539›Full record

ArticleCell2026

Advancing precision health discovery in a genetically diverse health system.

Roni Haas, Michael P Margolis, Angela Wei, Takafumi N Yamaguchi, Jeffrey Feng, Thai Tran, Veronica Tozzo, Katelyn J Queen, Mohammed Faizal Eeman Mootor, Vishakha Patil and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Roni HaasDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: rhaas@mednet.ucla.edu.
Michael P MargolisDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Angela WeiDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Interdepartmental Bioinformatics Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Takafumi N YamaguchiDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Jeffrey FengDepartment of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thai TranDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Veronica TozzoDepartment of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Katelyn J QueenDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mohammed Faizal Eeman MootorDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Vishakha PatilDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michael E BroudyUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Paul TungUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shafiul AlamUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Danielle B MartinezUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yash PatelDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Christa CaggianoInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10027, USA.
Nicole ZeltserDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rupert Hugh-WhiteDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Jaron ArbetDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ruhollah ShemiraniInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10027, USA.
Mao TianDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Prapti ThapaliyaUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lora EloyanUCLA Health Information Technology, Office of Health Informatics and Analytics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lawrence O ChenDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sandra LapinskaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maryam AriannejadInstitute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Clara LajonchereInstitute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
UCLA Precision Health Data Discovery Repository Working Group
UCLA Precision Health ATLAS Working Group
UCLA Health IT HPC Team
Regeneron Genetics Center
Eimear E KennyInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10027, USA; Center for Translational Genomics, Icahn School of Medicine, New York, NY 10027, USA; Division of Genomic Medicine, Department of Medicine, Icahn School of Medicine, New York, NY 10027, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, New York, NY 10027, USA.
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alex A T BuiJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Valerie A ArboledaDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Timothy S ChangDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Noah ZaitlenDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Paul T SpellmanDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: pspellman@mednet.ucla.edu.
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: pboutros@sbpdiscovery.org.
Daniel H GeschwindDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: dhg@mednet.ucla.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008042 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1985 to 2005
$6.0M
Uncovering the Genetic Mechanisms of the Chromosome 17q21.31 Tau Haplotype on Neurodegeneration Risk in FTD and PSPU54NS123746 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$2.0M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2002 to 2025
$1.3M
Identifying Undiagnosed Alzheimer’s Disease in Understudied PopulationsR01AG085518 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$738k
Biomedical Data Science Training Program for Precision Health EquityT15LM013976 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$248k
Medical Imaging Informatics Training GrantT32EB016640 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$218k
Identifying sources of variable penetrance and expressivity in monogenic diseases at population scaleF31HG013462 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$44k
Predicting prostate cancer clinical outcomes with germline genomic biomarkersF31CA281168 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$42k
Mapping cell type specific isoform diversity in the human brain: dissecting mechanisms of alternative splicing in ASDF30MH135712 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$42k
NCI NIH HHS F31 CA281168NHGRI NIH HHS F31 HG013462NHGRI NIH HHS R01 HG011345NHGRI NIH HHS T32 HG002536NIA NIH HHS K08 AG065519NIA NIH HHS R01 AG085518NIBIB NIH HHS T32 EB016640NIGMS NIH HHS T32 GM008042NIMH NIH HHS F30 MH135712NINDS NIH HHS U54 NS123746NLM NIH HHS T15 LM013976
6 · The paper itself

Abstract

Linking genetic data with electronic health records in hospital biobanks promises to advance precision medicine, but limited ancestral diversity constrains discovery and generalizability. We analyzed 93,936 participants from the UCLA ATLAS Community Health Initiative to inform disease prevalence and genetic risk across five continental and 36 fine-scale ancestry groups. We discovered numerous unreported gene-phenotype associations, including FN3K with intestinal disaccharidase deficiency in Europeans and admixed Americans. Polygenic scores (PGS) robustly predicted common diseases, with effects markedly diminished in non-Europeans. Furthermore, we reduced the pronounced European bias in curated clinical variants using computational predictors, uncovering unreported disease-gene associations, including ANKZF1 and peripheral vascular disease in African Americans. Longitudinal data revealed that semaglutide efficacy varies across ancestries, is associated with PGS for type 2 diabetes, and is modulated by genetic variation in PTPRU. These findings illustrate how ancestrally diverse biobanks from a single health system yield robust disease associations and pharmacogenomic insights.

Indexed as

Precision MedicineBlack or African AmericanDiabetes Mellitus, Type 2Electronic Health RecordsEuropean PeopleFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenetic VariationGenome-Wide Association StudyHumansMultifactorial InheritanceSemaglutideWhite PeopleSemaglutideancestryelectronic health recordsexome-wide association studygenetic associationgenomic medicineGLP-1 receptor agonistshealth-system biobankphenome-wide association studypolygenic scoressemaglutide

Identifiers

PMID41903539
PMCPMC13353064

What Socratic holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.