Evidence map›Paper›PMID 41903750›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Simultaneous myocardial T1, T2, T1ρ and fat fraction mapping with hybrid dual-echo cartesian acquisition and dictionary matching.

Zhenfeng Lyu, Hongzhang Huang, Haotian Hong, Junpu Hu, Yali Wu, Xianling Qian, Liwei Hu, Yumin Zhong, Mengsu Zeng, Peng Hu and 1 more

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Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Zhenfeng LyuSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Hongzhang HuangSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Haotian HongSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Junpu HuUnited Imaging Healthcare, Inc., Shanghai, China.
Yali WuShanghai Institute of Medical Imaging, Shanghai, China; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xianling QianShanghai Institute of Medical Imaging, Shanghai, China; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Liwei HuDepartment of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai 200127, China.
Yumin ZhongDepartment of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai 200127, China.
Mengsu ZengShanghai Institute of Medical Imaging, Shanghai, China; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Peng HuSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Haikun QiSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. Electronic address: qihk@shanghaitech.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT1, T2, T1ρ and fat fraction (FF) are important parameters for diagnosing various pathological changes in the myocardium. However, existing methods either require repeated breath-holds to quantify multiple parameters, or rely on complex image reconstruction to remove artifacts arising from highly undersampled acquisition. To address this technical gap, a free-breathing Dixon-MultiMap technique is proposed to allow for simultaneous myocardial T1, T2, T1ρ and FF mapping in a single scan with conventional single-shot Cartesian acquisition.

methodsDixon-MultiMap employs electrocardiogram-triggered, single-shot dual-echo Cartesian acquisition over 14 consecutive cardiac cycles. A hybrid dual-echo acquisition scheme is designed to acquire four-echo images within a short cardiac acquisition window in the first two cardiac cycles, which are used to obtain FF and B0 field maps with water-fat separation. The derived B0 map is used as prior information for dual-echo water-fat separation of the multi-contrast images acquired in the following cardiac cycles. Subsequently, dictionary matching is performed on the water images for multi-parameter mapping, accounting for spin-history B1+ inhomogeneities. Dixon-MultiMap was optimized through simulations and validated in phantoms, 13 healthy volunteers, and three patients with suspected hypertrophic cardiomyopathy.

resultsIn phantoms, Dixon-MultiMap showed strong correlation with reference methods for measuring T1, T2, T1ρ and FF (R² > 0.96). In healthy subjects, Dixon-MultiMap achieved robust water-fat separation, yielding FF comparable to the conventional multi-echo method. Compared with separate breath-hold mapping techniques, Dixon-MultiMap yielded significantly higher T1 values (1348 ± 33 ms vs. 1159 ± 28 ms, p < 0.001), comparable T2 values (46.4 ± 1.7 ms vs. 45.4 ± 1.5 ms, p = 0.96), and a small but statistically significant increase in T1ρ values (55.8 ± 2.6 ms vs. 53.0 ± 1.8 ms, p = 0.01). Pathological changes detected by Dixon-MultiMap were consistent with those identified using conventional mapping techniques in the three patients.

conclusionThe proposed Dixon-MultiMap allows for simultaneous myocardial T1, T2, T1ρ and FF mapping in a free-breathing acquisition of 14 cardiac cycles. Water-fat partial volume was resolved by water-fat separation in Dixon-MultiMap, which improved the accuracy of multi-parameter estimation.

Indexed as

Adipose TissueAdiposityCardiomyopathy, HypertrophicImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMyocardiumAdultCardiac-Gated Imaging TechniquesElectrocardiographyFemaleHealthy VolunteersHumansMalePhantoms, ImagingPredictive Value of TestsReproducibility of ResultsDictionary matchingFat fractionFree breathingHybrid dual-echoMulti-parametric mappingT1ρ mappingWater-fat separation

Identifiers

PMID41903750
PMCPMC13237549

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.