Evidence map›Paper›PMID 41903756›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Endogenous targeting lipid nanoparticles for systemic mRNA delivery to lung cancer tumors.

Yoon Tae Goo, Vladislav Grigoriev, Tetiana Korzun, Ammar Salem, Kongbrailatpam Shitaljit Sharma, Prem Singh, Chrissa Kioussi, Olena R Taratula, Daniel L Marks, Oleh Taratula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Single-ligand dual-targeting lipid nanoparticles for therapeutic mRNA delivery to glioblastoma across the blood-brain barrier.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoon Tae GooDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA; College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
Vladislav GrigorievDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Tetiana KorzunDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Ammar SalemDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Kongbrailatpam Shitaljit SharmaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Prem SinghDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Chrissa KioussiDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Olena R TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA.
Daniel L MarksEndevica Bio, 1935 Techny Rd, Northbrook, IL 60062, USA.
Oleh TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon 97201, USA. Electronic address: oleh.taratula@oregonstate.edu.

Funding

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer CachexiaR37CA234006 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2019 to 2025
$3.2M
Intravascular Delivery of Nanoclusters for Treatment of Deep-Seated Cancers with Magnetic HyperthermiaR01CA237569 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2020 to 2024
$2.7M
Nanoparticle-mediated placental imaging and magnetic hyperthermia for management of ectopic pregnancyR01HD112007 · NICHD · OREGON STATE UNIVERSITY · PI Olena Taratula · 2023 to 2026
$2.4M
Development of magnetic hyperthermia for the systemic treatment of endometriosisR01HD101450 · NICHD · OREGON STATE UNIVERSITY · PI SLAYDEN, OV D, TARATULA, OLEH · 2021 to 2024
$2.4M
NCI NIH HHS R01 CA237569NCI NIH HHS R37 CA234006NICHD NIH HHS R01 HD101450NICHD NIH HHS R01 HD112007
6 · The paper itself

Abstract

Systemic delivery of mRNA therapeutics to lung cancer tumors remains challenging despite recent advances in organ-targeting lipid nanoparticles (LNPs). This study introduces novel LNPs, comprising commercially available DC-cholesterol (a cationic derivative of cholesterol) and 113-O12B ionizable lipid (DC_113), which provide selective mRNA translation in healthy lungs while achieving preferential protein expression in pulmonary tumors compared to adjacent lung tissue in an orthotopic cancer model. Analysis of LNPs with diverse ionizable lipids revealed that DC_113 has an apparent pK

Indexed as

LipidsLung NeoplasmsNanoparticlesRNA, MessengerAnimalsCachexiaCell Line, TumorFemaleFollistatinHumansLiposomesMiceVitronectinFollistatinLipid NanoparticlesLipidsLiposomesRNA, MessengerVitronectin113-O12B/DC-cholesterolcachexiaEndogenous targetingmRNA LNPVitronectin

Identifiers

PMID41903756
PMCPMC13135778

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.