ReviewTrends in endocrinology and metabolism: TEM2026
Improving incretin-mediated body weight loss via energy expenditure.
Review in Trends in endocrinology and metabolism: TEM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Incretin-based therapies have transformed obesity and type 2 diabetes treatment. While current therapeutics safely reduce food intake and lower body weight, a compensatory drop-in basal metabolic rate represents a barrier to sustainable weight loss. Current efforts aim to incorporate energy expenditure (EE) stimulation with the anorectic actions currently available in the clinic. Glucagon receptor agonism, for instance, has demonstrated the benefit of a multipronged increase in EE; however, compensatory challenges persist. We detail peripheral mechanisms that can increase EE independent of activity and the key central mechanisms controlling them. Understanding the complex interplay between these mechanisms and their central modulation is critical for a coordinated engagement of EE pathways to complement and improve current weight loss treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.