Evidence map›Paper›PMID 41904330›Full record

ArticleCommunications biology2026

Single-cell transcriptome-wide Mendelian randomization during CD4

Honghan Zhang, Honggang Lyu, Qian Gong, Chao Wang, Qi Wang, Wei Wang, Kun Li, Zhongchun Liu

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Honghan Zhang *Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Honggang Lyu *Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0002-6272-3533
Qian GongDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Chao WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Qi WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Wei WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Kun LiDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Zhongchun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China. zcliu6@whu.edu.cn.ORCID http://orcid.org/0000-0001-5410-0312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many neuropsychiatric disorders are driven by immunity, but the specific underlying mechanisms and how best to exploit them for therapy remain elusive. Here we combine single-cell transcriptomics of dynamic T cell activation states, identification of expression quantitative trait loci, and Mendelian randomization and colocalization analyses to identify causative genes, pathways, and drug targets in Alzheimer's disease (AD) and major depressive disorder (MDD). During CD4

Indexed as

Alzheimer DiseaseCD4-Positive T-LymphocytesLymphocyte ActivationMajor Depressive DisorderTranscriptomeGene Expression ProfilingHumansMendelian Randomization AnalysisQuantitative Trait LociSingle-Cell AnalysisSingle-Cell Gene Expression Analysis

Identifiers

PMID41904330
PMCPMC13195081

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.