ReviewCellular and molecular life sciences : CMLS2026
From molecular mechanisms of glycosphingolipid function to bio-therapeutic applications.
Review in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Network Clustering Approach Reveals Key Proteins and Biological Functions in the Response of Whiteleg Shrimp (Penaeus vannamei) to Acute Hepatopancreatic Necrosis Disease.Marine biotechnology (New York, N.Y.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Glycosphingolipids (GSLs) are regulators of membrane organization and trafficking. According to the glycolipid-lectin (GL-Lect) driven endocytosis model, GSLs are part of a mechanism in which they are used by oligomeric lectins from pathogens or cells to build tubular endocytic pits from which clathrin-independent endocytic carriers detach by friction-driven scission. This review revisits the unique architectural logic of GSLs and explores how this underpins mechanisms for endocytic trafficking and signaling. We examine notably how GSLs orchestrate retrograde trafficking from the plasma membrane to the Golgi apparatus and subsequent polarized secretion in specialized contexts such as migrating cells, epithelial tissues, and immune synapses. Despite their importance, GSL functions have remained difficult to explore, because of the scarcity of minimally perturbing, chemically defined tools. We survey recent development in GSL probe design and discuss principles for next-generation tools that retain native function while enabling mechanistic dissection. Finally, we discuss how these advances are reshaping therapeutic strategies, with implications for vaccine delivery, cancer targeting, and lysosomal storage disorders. Collectively, this review reframes GSLs as substrates of membrane organization, with vast untapped potential in both cellular membrane biology and translational medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.