Evidence map›Paper›PMID 41905533›Full record

ArticleVirologica Sinica2026

Tupaia belangeri better reflects the typical symptoms of Chikungunya virus infection than mice: A comparative study.

Yan Guo, Mengyuan Zheng, Qi Wang, Hui Xiao, Li Liu, Shuwei Dong, Yonghan Luo, Zhouling Pan, Yujie Xiang, Yanxian Jiang and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yan GuoFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China; Department of Reproductive Gynecology & NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People's Hospital of Yunnan Province, Kunming 650032, China; Department of Reproductive Gynecology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.
Mengyuan ZhengFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Qi WangFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Hui XiaoFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Li LiuFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Shuwei DongFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Yonghan LuoFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Zhouling PanFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Yujie XiangFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Yanxian JiangFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Xiao ChenFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China.
Hailin TangDepartment of Microbiology, Naval Medical University, Shanghai 200433, China. Electronic address: hailint@163.com.
Yuemei FengSchool of Public Health & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming Medical University, Kunming 650500, China. Electronic address: fengyuemei2013@163.com.
Yue FengFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: fyky2005@163.com.
Xueshan XiaFaculty of Life Science and Technology & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming University of Science and Technology, Kunming 650500, China; School of Public Health & Yunnan Province Key Laboratory of Public Health and Biosafety, Kunming Medical University, Kunming 650500, China. Electronic address: oliverxia2000@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya virus (CHIKV) infection in humans is typically characterized by acute febrile illness, rash, and polyarthralgia, and often progresses to chronic arthralgia. However, existing small-animal models fail to capture both the acute and chronic phases of the disease. In this study, we compared Chinese tree shrews (Tupaia belangeri) and C57BL/6 mice in terms of infection dynamics, viral characteristics, histopathological changes, and immune responses. Following dual-site inoculation (subcutaneous injection into the abdomen and footpad), Tupaia belangeri exhibited typical symptoms that more closely resembled those of humans, including pronounced fever, foot swelling, and skin lesions, and were accompanied by higher and more sustained viral loads in blood and multiple tissues. Histopathological examination revealed marked inflammation and tissue damage in muscle and joint tissues, consistent with pathological changes observed in humans. Transcriptomic analysis further demonstrated significant upregulation of multiple key immune-related genes (CXCL10, ISG15, IFIT3, SERPING1, MCEMP1, IFI6), indicating a human-like immune response profile. Collectively, our results show that Tupaia belangeri faithfully mirrors the infection features, viral dynamics, and immune responses of human CHIKV infection, establishing it as a valuable model for dissecting disease mechanisms and testing vaccines or antiviral therapies.

Indexed as

Chikungunya FeverChikungunya virusDisease Models, AnimalTupaiaAnimalsFemaleGene Expression ProfilingHumansMaleMiceMice, Inbred C57BLViral LoadAnimal modelCHIKVChronic arthritisTranscriptomic analysisTree shrews (Tupaia belangeri)Viral persistence

Identifiers

PMID41905533
PMCPMC13556353

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.