Evidence map›Paper›PMID 41905562›Full record

ReviewNeuroscience and biobehavioral reviews2026

Neurodevelopmental effects of early life stress: PFC and cognition.

Lital Rachmany, Fabiula Abreu, Victoria Walker, Olivia O'Neill, Derya Sargin, Cátia M Teixeira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lital RachmanyEmotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Fabiula AbreuEmotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Victoria WalkerEmotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Olivia O'NeillDepartment of Psychology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
Derya SarginDepartment of Psychology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
Cátia M TeixeiraEmotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: catia.teixeira@nki.rfmh.org.

Funding

Modulation of serotonin levels during development produce long-lasting changes in dopaminergic functionR01HD095966 · NICHD · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI TEIXEIRA, CATIA · 2019 to 2023
$2.0M
Role of PFC Activity in the Behavioral Deficits Induced by Maternal SeparationR01HD110541 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Catia Teixeira · 2023 to 2026
$1.9M
Maternal presence modulates pups' brain activity via the serotonergic systemR03HD094978 · NICHD · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI TEIXEIRA, CATIA · 2018 to 2019
$162k
NICHD NIH HHS R01 HD095966NICHD NIH HHS R01 HD110541NICHD NIH HHS R03 HD094978
6 · The paper itself

Abstract

Early life stress (ELS) exerts lasting effects on prefrontal cortex (PFC) development and function, contributing to cognitive and emotional vulnerabilities later in life. This review synthesizes findings from human studies and animal models showing that ELS disrupts PFC-dependent cognitive functions, including executive control, attention, working memory, and decision-making. We examine how ELS alters functional connectivity, neurotransmitter systems such as serotonin, GABA, and Dopamine, and hormonal signaling, particularly glucocorticoid regulation. Finally, we explore evidence for epigenetic mechanisms within the PFC that mediate the long-term impact of ELS on cognition and mental health.

Indexed as

Adverse Childhood ExperiencesCognitionPrefrontal CortexStress, PsychologicalAnimalsHumansNeurodevelopmentCognitionDevelopmentEarly-life stressPrefrontal cortexSerotonin

Identifiers

PMID41905562
PMCPMC13094373

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.