Evidence map›Paper›PMID 41906042›Full record

ArticleCommunications biology2026

A spatiotemporal transcriptomic atlas of porcine (Sus scrofa) female early gonadal development.

Pengcheng He, Wenzhe Xia, Tianzhi Chen, Yaxuan Yan, Dengfeng Gao, Yadi Teng, Ting Zhao, Xinze Chen, Zhiqiang Feng, Runbo Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pengcheng He *Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Wenzhe Xia *Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Tianzhi Chen *Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-2481-6448
Yaxuan Yan *Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Dengfeng Gao *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Yadi TengFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Ting ZhaoFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xinze ChenFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhiqiang FengFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Runbo LiFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Meng WangFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yuwen KeFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. keyw@cau.edu.cn.
Jianyong HanFrontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. hanjy@cau.edu.cn.ORCID http://orcid.org/0000-0002-9549-3279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early gonads of mammals contain primordial germ cells (PGCs) and gonadal somatic cells. In females, the gonadal somatic cells promote the specification of PGCs into oogonia and their entry into meiosis, which is crucial for oogenesis. Although single-cell transcriptome sequencing technology holds significant advantages in cell type identification, its inability to resolve spatial positional information substantially hampers research on communication mechanisms between germ cells and adjacent somatic cells. Here, we utilized high-resolution spatial transcriptomic technology to dissect the spatial dynamics of various cell types during the specification of PGCs into oogonia and their entry into meiosis in porcine gonads. We clarified the spatial localization of two waves of granulosa cells in the supporting cell lineage and their roles in regulating germ cell development. Furthermore, we found that interstitial and endothelial cells were predominantly located in the medullary region of the early gonads. Notably, cell-cell communication analysis revealed the critical role of BMP signaling (BMP2, BMP4 and GDF5) in driving the specification of PGCs into oogonia and their subsequent entry into meiosis. Our study provides a spatially resolved understanding of the PGC-to-oogonia specification in vivo and offers critical resources for reconstituting oogenesis in vitro.

Indexed as

GonadsOvarySus scrofaTranscriptomeAnimalsFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGerm CellsGranulosa CellsMeiosisOogenesisOogoniaSignal TransductionSingle-Cell Gene Expression AnalysisSpatial Transcriptomics

Identifiers

PMID41906042
PMCPMC13050328

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.