Trial reportHypertension (Dallas, Tex. : 1979)2026
Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity.
Trial report in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundAlthough some individuals exhibit salt sensitivity, others demonstrate salt resistance or inverse salt sensitivity-blood pressure reduction during a high-sodium diet. The molecular mechanisms underlying heterogeneous blood pressure responses to dietary sodium remain poorly understood.
methodsWe conducted a randomized crossover trial in 20 adults (blood pressure <140/90 mm Hg), comparing 8-day low-sodium (10 mmol/d) versus high-sodium (300 mmol/d) diets. Plasma proteomics used SomaLogic's 7K v4.1 platform (≈7000 proteins). Protein changes between diets were compared with blood pressure changes.
resultsDespite higher weight (+1.4 kg) during high-sodium diet (
conclusionsSVEP1 emerges as a key molecular correlate of blood pressure responses to dietary sodium, likely through a volume- or stretch-mediated stimulus. Given SVEP1's established functions in vascular smooth muscle relaxation and lymphangiogenesis, these findings suggest novel pathways mediating cardiovascular adaptation to sodium challenges and potential biomarkers for identifying salt-sensitive versus salt-resistant individuals.
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