Evidence map›Paper›PMID 41907011›Full record

SynthesisJournal of periodontal research2026

Artificial Intelligence in Periodontology: A Systematic Review.

Antonin Tichy, Nils Werner, Helena Dujic, Charlotte Wetzel, Vinay Pitchika, Caspar Victor Bumm, Matthias Folwaczny, Falk Schwendicke

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of periodontal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonin TichyDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-6260-9992
Nils WernerDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-8498-0736
Helena DujicDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-9829-4427
Charlotte WetzelDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-5874-0448
Vinay PitchikaDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-6947-2602
Caspar Victor BummDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.
Matthias FolwacznyDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.
Falk SchwendickeDepartment of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, LMU Munich, Munich, Germany.ORCID https://orcid.org/0000-0003-1223-1669

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo provide a comprehensive review of artificial intelligence (AI) applications in periodontology, focusing (1) on deep learning for image-based diagnosis of periodontitis and (2) on non-image-based AI applications across periodontal care.

methodsThis study adhered to PRISMA guidance. Six databases (PubMed, Scopus, Web of Science, Embase/Ovid, IEEE Xplore, and arXiv) were searched. The first review question (PICO 1) focused on applications of deep learning to human imaging data for diagnosing periodontitis, and the systematic review was followed by a modified QUADAS-2 risk-of-bias (RoB) assessment. The second part (PICO 2) scoped AI applications in periodontology using non-imaging data. Because of substantial heterogeneity in tasks, inputs, and outcomes, PICO 2 was synthesized narratively without formal RoB assessment.

resultsPICO 1 included 29 studies, predominantly using panoramic radiographs (n = 21). Binary periodontitis classification achieved accuracies of 81%-99% on panoramic radiographs and 78% on CBCT, whereas staging/severity showed lower performance (accuracy 64%-91% in panoramic radiographs; 83% in intraoral radiographs with AUROC 0.84-0.93). Photograph-based screening achieved AUROC 0.93. RoB was generally low, but applicability concerns were frequent, mainly because of single-center datasets. PICO 2 included 65 studies, covering diagnosis and classification of periodontitis (AUROC 0.77-0.85), risk stratification and screening (AUROC 0.60-0.98), progression, and treatment outcome modeling (AUROC 0.58-0.89), oral-systemic associations, biomarker identification, and clinical data mining using natural language processing, which achieved near-perfect metrics.

conclusionGeneralizability remains the key limitation across applications, driven by limited data diversity, inconsistent tasks/metrics, and scarce external testing. Future studies should prioritize multicenter evaluation, transparent reporting, and prospective assessments of workflow impact and patient-related outcomes. REGISTRATION: PROSPERO identification number CRD420251128758.

Indexed as

Artificial IntelligencePeriodonticsPeriodontitisDeep LearningHumansRadiography, Panoramicclinical decision supportdeep learningdental imagingdiagnostic accuracymachine learningperiodontitisrisk prediction

Identifiers

PMID41907011
PMCPMC13471768

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.