ReviewFrontiers in molecular biosciences2026
Non-coding RNA biomarkers in resistant hypertension: a scoping review.
Review in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To map and synthesize human evidence on circulating non-coding RNAs (ncRNAs) evaluated as biomarkers in resistant hypertension (RH), including associations with RH phenotypes, target-organ damage, and short-term treatment response. Methods: A scoping review was conducted and reported in line with PRISMA-ScR guidance. PubMed, Web of Science, and Google Scholar were searched using RH-related terms combined with ncRNA keywords. After deduplication, titles/abstracts and full texts were screened in Covidence. Eligible records included full-length articles and conference abstracts reporting original human research explicitly addressing RH; case reports, narrative reviews, and animal/in vitro-only studies were excluded. Data were charted using a standardized extraction form and synthesized qualitatively due to heterogeneity. Results: Eight studies met inclusion criteria (five full-length articles and three congress abstracts) published between 2013 and 2024. Across studies, RH sample sizes ranged from 10 to 115 (total RH participants: 338; mean ≈ 42 per study). All studies assessed peripheral-blood matrices (serum, plasma, or PBMCs) and focused on microRNAs (miRNAs) or circular RNAs (circRNAs); no eligible study evaluated other circulating ncRNA classes (e.g., lncRNAs, snoRNAs, siRNAs, piRNAs) specifically in RH. Evidence clustered into four clinical contexts: baseline RH comparisons (and separately, internal comparison of RH with versus without type 2 diabetes mellitus), RH with obstructive sleep apnoea (OSA) and blood-pressure response to CPAP, RH with and without OSA, and RH treated with renal sympathetic denervation (RDN). Reported signals included elevated serum miR-21 in RH versus comparators (AUC ≈0.82 in one study), higher PBMC miR-1-1 and miR-195 in RH with diabetes, a three-miRNA panel (miR-378a-3p/miR-486-5p/miR-100-5p) discriminating CPAP responders versus non-responders (AUCs ≈0.88 training and ≈0.92 validation), increased miR-133a after RDN (≈7.2-fold), and early post-RDN circRNA changes (hsa_circRNA_000367↑; hsa_circRNA_405119↓). Methodology (platforms and normalization) and analytic rigor varied substantially; most analyses were univariable and external validation was absent. Conclusion: Human evidence on circulating ncRNA biomarkers in RH is sparse and fragmented. Although individual studies have reported biologically plausible associations between selected miRNAs/circRNAs and RH-related phenotypes or short-term treatment response, current data are insufficient for clinical implementation. Larger, well-phenotyped, multicentre studies using standardized assays and independent, robust multivariable validation are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.