Evidence mapPaperPMID 41907161Full record

ReviewACS nutrition science2026

Urinary Metabolites during Pregnancy: A Literature Review.

Shiyi Y L Xie, Amar Hamdan, Sarah S Comstock

Abstract readReview
In one paragraph

Review in ACS nutrition science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shiyi Y L XieDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, United States.
Amar HamdanDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, United States.ORCID https://orcid.org/0009-0006-6989-0779
Sarah S ComstockDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, United States.ORCID https://orcid.org/0000-0003-3107-7652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary metabolites provide information regarding metabolic changes and environmental exposure throughout pregnancy. A narrative literature review was conducted by using PubMed and Web of Science. Included studies enrolled pregnant women aged ≥18 years and analyzed urinary metabolites in relation to prepregnancy body mass index (BMI) or trimester of pregnancy. Environmental and dietary exposures were also considered. Thirteen studies met the criteria. Women with a higher prepregnancy BMI have unique urinary metabolite profiles, including lower levels of glucogenic amino acids and long-chain acylcarnitines, reflecting disturbances in amino acid and lipid metabolism. The third trimester was marked by elevated urinary cortisol, carboxylic acids, glycerolipids, and steroid derivatives. Environmental exposures such as diet, phthalates, metals, and parabens were linked to distinct urinary metabolite patterns. More comprehensive analyses of urinary metabolites during pregnancy in diverse populations are needed to identify early metabolic risks and develop targeted prenatal interventions to improve maternal and fetal health outcomes.

Indexed as

metabolomicspregnancyprepregnancy BMItrimesterurinary metabolites

Identifiers

PMID41907161
PMCPMC13019795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.