ArticleFrontiers in medicine2026
Comparative effects of 1.25 vs. 1.5 mmol/L dialysate calcium concentrations on blood pressure variability during hemodialysis: a two-center retrospective study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hemodialysis patients frequently experience blood pressure fluctuations, which are independently associated with adverse cardiovascular outcomes. However, the optimal dialysate calcium concentration for minimizing blood pressure variability (BPV) remains controversial. Methods: This retrospective cohort study investigated the differential effects of dialysate calcium concentrations of 1.25 mmol/L (DCa 1.25) versus 1.5 mmol/L (DCa 1.5) on intradialytic BPV. We analyzed 2,061 hemodialysis sessions from 711 maintenance hemodialysis patients across two centers in China. Patients were categorized based on dialysate calcium concentration: 1.25 mmol/L ( Results: Compared with DCa 1.5, group DCa 1.25 demonstrated significantly lower systolic blood pressure variability (SBPV) (25.23 ± 14.55 vs. 32.42 ± 17.71 mmHg, Discussion: These findings suggest that lower dialysate calcium concentration may improve hemodynamic stability during hemodialysis by minimizing calcium flux and associated blood pressure fluctuations.
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