ArticleFrontiers in medicine2026
Diagnostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and lymphocyte-to-monocyte ratios for assessing organ and multiorgan involvement in sarcoidosis: a retrospective single-center study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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11 authors.
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Abstract
Background: Sarcoidosis is a heterogeneous disease lacking reliable biomarkers for organ involvement. Indices derived from the complete blood count (CBC), including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have emerged as accessible markers of systemic inflammation. Objectives: To assess whether CBC parameters and NLR, PLR, and LMR vary across demographic and clinical features in sarcoidosis, and to evaluate their diagnostic performance for organ-specific and multiorgan involvement. Methods: A retrospective, single-center observational study included adults with sarcoidosis diagnosed between 2000 and 2025. Age- and sex-adjusted logistic regression evaluated associations between hematologic indices at diagnosis and organ involvement. Additional logistic regression using analytical parameters evaluated associations between blood count-derived ratios and multiorgan involvement. Firth's correction was applied when the events-per-variable ratio was < 10, and analyses were repeated using log-transformed hematologic ratios when skewness coefficient > 2. Diagnostic performance was assessed by receiver operating characteristic (ROC) curve analysis. Results: A total of 229 patients were included (mean age 51.34 years; 57.64% women). Median values for NLR, PLR, and LMR were 2.57, 158.97, and 3.17, respectively. Higher NLR and PLR were independently associated with extrathoracic lymph node involvement (NLR: OR = 13.42, 95% CI 1.91-94.32, Conclusion: NLR was independently associated with multiorgan disease, splenic and extrathoracic lymph node involvement. PLR was independently associated with extrathoracic lymph node involvement.
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