Evidence map›Paper›PMID 41907257›Full record

ArticleFrontiers in medicine2026

Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts.

Ana Luisa Calixto Rodrigues, Samantha Kuwada Teixeira, Antonio Luiz Pinho Ribeiro, Ester Cerdeira Sabino, Isabela Judith Martins Benseñor, Paulo Andrade Lotufo, Jose Eduardo Krieger, Alexandre da Costa Pereira

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Ana Luisa Calixto RodriguesLaboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Samantha Kuwada TeixeiraLaboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Antonio Luiz Pinho RibeiroDepartment of Internal Medicine, Telehealth Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil.
Ester Cerdeira SabinoDepartment of Infectious Diseases, University of São Paulo Medical School, São Paulo, Brazil.
Isabela Judith Martins BenseñorCenter for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, Brazil.
Paulo Andrade LotufoCenter for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, Brazil.
Jose Eduardo KriegerLaboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Alexandre da Costa PereiraLaboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Most polygenic risk scores (PRS) are derived and validated using genetic data from European populations. However, European-based PRS perform poorly in individuals of non-European ancestry, and their transferability to the admixed Brazilian population remains unknown. Methods: PRS derived from the United Kingdom Biobank (UKB) were selected from the PGS Catalog, including 33 scores for body mass index (BMI), 36 for systolic blood pressure (SBP), and 33 for diastolic blood pressure (DBP). PRS were applied to 4,758 participants from two geographically distinct Brazilian cohorts (São Paulo and North Minas Gerais) and a UKB sample. Performance was evaluated across self-identified racial subgroups and in Brazilian individuals genetically similar to the UK sample, as determined by genomic clustering techniques (Uniform Manifold Approximation and Projection, UMAP; and Principal Component Analysis, PCA). Effect sizes were compared using multivariable mixed-effects models. Results: Most BMI PRS were validated in São Paulo (96.7%) and North Minas Gerais (90.9%), whereas blood pressure PRS showed lower validation rates (SBP: 66.7 and 38.9%; DBP: 69.7 and 54.5%, respectively). Validated PRS consistently exhibited lower effect sizes in Brazilian cohorts compared to the UKB ( Conclusion: European-derived PRS are not directly transferable to the Brazilian population without prior empirical validation. Regional origin, self-identified race, and genetic similarity to the UKB do not reliably identify Brazilian subgroups with differential PRS performance. These findings highlight the urgent need for polygenic scores derived and trained on Brazilian genomic data.

Indexed as

admixed populationsblood pressurebody mass indexhypertensionobesitypolygenic risk score

Identifiers

PMID41907257
PMCPMC13021482

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.