Evidence map›Paper›PMID 41907315›Full record

ArticleBrain communications2026

Ertugliflozin improves animal behaviours associated with oxidative stress and inflammation in a BTBR

Xiaona Wang, Zhengqin Zhao, Limin Sun, Chao Gao, Li Wang, Daoqi Mei, Chanjuan Hao, Shuai Zhao, Xingxue Yan, Jing Liu and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xiaona WangHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.
Zhengqin ZhaoDepartment of Nuclear Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Limin SunShanghai Institute of Microsystem and Information Technology, Shanghai, China.
Chao GaoDepartment of Rehabilitation, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Li WangDepartment of Neurology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Daoqi MeiDepartment of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, China.
Chanjuan HaoBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Genetics and Birth Defects Control Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Shuai ZhaoHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.
Xingxue YanHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.
Jing LiuHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.
Lei LiuHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.
Bin GuoPhysiology and Psychology Section, Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Regional High Incidence Disease, Ningxia Medical University, Yinchuan City 750004, China.
Yaodong ZhangHenan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Henan Academy of Medical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Institute of Children's Health, Zhengzhou 450018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder is a neurodevelopmental condition typified by difficulties in social interactions, repetitive and restricted behaviour and heightened anxiety. Increasing evidence suggests that oxidative stress and neuroinflammatory processes are crucial in the development of these behavioural abnormalities. Ertugliflozin, a sodium-glucose cotransporter-2 inhibitor approved by the FDA for treating type 2 diabetes mellitus, has also been reported to exert antioxidant and anti-inflammatory effects. BTBR

Indexed as

autism spectrum disorderertugliflozininflammationmicrogliaoxidative stress

Identifiers

PMID41907315
PMCPMC13022961

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.