Evidence map›Paper›PMID 41907405›Full record

ArticleiScience2026

Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems.

Zhe Wei, Xiaojie Zhou, Boyu Li, Junjie Gu, Laixiang Ge, Fan Tang, Mingyan Lin, Ying Jin

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe WeiDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China.
Xiaojie ZhouDepartment of Neurobiology, School of Basic Medical Science, Nanjing Medical University, Nanjing 211166, China.
Boyu LiDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China.
Junjie GuDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Laixiang GeDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Fan TangDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Mingyan LinDepartment of Neurobiology, School of Basic Medical Science, Nanjing Medical University, Nanjing 211166, China.
Ying JinCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique gene expression program driving early human brain development remains incompletely defined. In this study, we profile and compare transcriptomes of human and mouse embryo central nervous system (CNS) across Carnegie stages (CS) 11-14, a critical window spanning neural tube closure to early brain regionalization, including 4 CNS regions at CS13-14. Our analysis reveals that human CNS is less mature than mouse CNS at CS13-14. Extracellular matrix (ECM) organization/structure emerges as the most divergent biological process, underscoring species-specific ECM roles in early CNS development. Co-expression module analysis reveals CS14 as the most conserved stage, CS12-13 as the most divergent, and CS11 as encompassing both conserved and species-specific events. Early spinal cord development shares regulatory mechanisms between species. This study uncovers previously unrecognized spatiotemporal/species-specific gene expression features, offering a valuable resource for Alzheimer's disease (AD) developmental origin research and highlighting ECM pathways as promising regenerative medicine targets.

Indexed as

Developmental biologyExpression studyModel organismTranscriptomics

Identifiers

PMID41907405
PMCPMC13018895

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.