Evidence map›Paper›PMID 41907414›Full record

ArticleiScience2026

CGF induces ROS-mediated metabolic reprogramming and mitochondrial dysfunction to suppress colorectal cancer progression.

Jiebang Jiang, Xinxin Zhang, Yipeng Sun, Jing Chen, Bo Yuan, Xincheng Li, Xi Chen, Xin Chen, Rongpeng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiebang JiangSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Xinxin ZhangSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Yipeng SunSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Jing ChenSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Bo YuanSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Xincheng LiJingwen Academy, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Xi ChenSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Xin ChenDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Rongpeng LiSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating effective therapeutic strategies. This study investigates the antitumor properties and mechanism of Cya-Gly-Fer (CGF), a natural anthocyanin derivative. Using CRC cell lines, organoids, and xenograft models, we show that CGF significantly inhibits tumor growth and metastasis. Integrated transcriptomics and metabolomics indicate that CGF disrupts central carbon metabolism and oxidative phosphorylation. Mechanistically, CGF downregulation of ABC transporters causes intracellular ATP accumulation, triggering mitochondrial dysfunction and excessive reactive oxygen species (ROS) generation. This metabolic stress suppresses the MAPK/ERK1/2/c-MYC signaling axis, leading to cell-cycle arrest and apoptosis. These findings identify CGF as a potent agent that targets mitochondrial homeostasis to halt CRC progression.

Indexed as

Cell biologyMolecular biologyOmics

Identifiers

PMID41907414
PMCPMC13018894

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.