Evidence map›Paper›PMID 41907445›Full record

ArticleiScience2026

Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in

Takuto Suito, Xiangmei Deng, Shoma Sato, Kohjiro Nagao, Christian Ganser, Takayuki Uchihashi, Motosuke Tsutsumi, Tomomi Nemoto, Yuji Hara, Makoto Tominaga and 1 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takuto SuitoSection of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
Xiangmei DengSection of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
Shoma SatoSection of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
Kohjiro NagaoDepartment of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
Christian GanserExploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.
Takayuki UchihashiExploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.
Motosuke TsutsumiExploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.
Tomomi NemotoExploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.
Yuji HaraSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Makoto TominagaNagoya Advanced Research and Development Center, Nagoya City University, Nagoya, Japan.
Takaaki SokabeSection of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIEZO and TRP channels are receptors for physical stimuli such as mechanical touch and temperature in sensory neurons. As these receptors are localized in the plasma membrane, the modulation of their activities by membrane lipids has recently attracted attention. In this study, we focused on ether phospholipids (ePLs) enriched in neurons and analyzed their role in somatosensation using

Indexed as

cell biologyMechanobiologymodel organism

Identifiers

PMID41907445
PMCPMC13018890

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.