Evidence map›Paper›PMID 41907765›Full record

ArticleNature physics2026

Spontaneous switching in a protein signalling array reveals near-critical cooperativity.

Johannes M Keegstra, Fotios Avgidis, Evan Usher, Yuval Mulla, John S Parkinson, Thomas S Shimizu

Abstract read
In one paragraph

Article in Nature physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johannes M KeegstraAMOLF, Science Park 104, 1098XG Amsterdam, the Netherlands.
Fotios AvgidisAMOLF, Science Park 104, 1098XG Amsterdam, the Netherlands.
Evan UsherAMOLF, Science Park 104, 1098XG Amsterdam, the Netherlands.
Yuval MullaAMOLF, Science Park 104, 1098XG Amsterdam, the Netherlands.
John S ParkinsonSchool of Biological Sciences, University of Utah, 84112 Salt Lake City, Utah, USA.
Thomas S ShimizuAMOLF, Science Park 104, 1098XG Amsterdam, the Netherlands.

Funding

Intracellular Signaling by Bacterial ChemoreceptorsR01GM019559 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JOHN S PARKINSON · 1985 to 2026
$12.3M
The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
NIGMS NIH HHS R01 GM019559NIGMS NIH HHS R01 GM106189
6 · The paper itself

Abstract

Cooperative interactions within large protein assemblies are crucial for cellular information processing. However, direct observations of cooperative transitions have been limited to compact molecular assemblies. Here, we report

Identifiers

PMID41907765
PMCPMC13019169

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.