ArticleClinical ophthalmology (Auckland, N.Z.)2026
Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate whether glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy influences the risk of legal blindness and ischemic optic neuropathy (ION) among patients with type 2 diabetes mellitus (T2DM) and cardiovascular risk factors (CVRF). Design: A retrospective cohort study using de-identified electronic medical record (EMR) data from TriNetX, encompassing 72 healthcare organizations across the United States between January 2018 and January 2025. Participants: Adults (≥18 years) with T2DM (A1c <10%) and at least one CVRF (hyperlipidemia, essential hypertension, overweight/obesity, or chronic ischemic heart disease) who were prescribed or not prescribed a GLP-1 RA. Methods: Patients with type 1 diabetes, optic neuritis, giant cell arteritis, or phosphodiesterase-5 inhibitor use were excluded. GLP-1 RA users were required to have ≥2 prescription records. A 1:1 propensity score matching (PSM) was performed to balance demographics, comorbidities, laboratory values, and concurrent antidiabetic medications. Outcomes were assessed at 1-, 3-, and 5-year follow-ups. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using univariable survival analyses. Main Outcome Measures: Incidence of legal blindness and ischemic optic neuropathy. Results: After PSM, each cohort included 350,536 patients (mean age 58.7 ± 12.6 years; 61.6% female). GLP-1 RA use was associated with a significantly reduced risk of legal blindness at 1 year (HR 0.589, 95% CI 0.476-0.728), 3 years (HR 0.677, 95% CI 0.583-0.788), and 5 years (HR 0.669, 95% CI 0.583-0.768). There was no significant difference in ION incidence between cohorts at 1 year (HR 0.872, 95% CI 0.627-1.212), 3 years (HR 1.002, 95% CI 0.792-1.268), or 5 years (HR 0.978, 95% CI 0.789-1.211). Conclusion: GLP-1 receptor agonist therapy was associated with a significantly lower risk of legal blindness and no difference in ION incidence. These findings indicate potential ocular benefits of GLP-1 RAs beyond glycemic and cardiovascular outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.