SynthesisFrontiers in aging neuroscience2026
Efficacy of Dang Gui Shao Yao San in treating vascular dementia in animal models: a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vascular dementia (VaD) is the second most prevalent form of dementia, following Alzheimer's disease (AD), and severely impacts life quality of patients. Currently, effective strategies to alleviate symptoms and delay disease progression remain unavailable. Animal studies indicate that Dang Gui Shao Yao San (DGSYS) may enhance cognitive function in VaD models through mechanisms such as antioxidation and the enhancement of cerebral blood flow. However, a systematic review of its neuroprotective effects and a comprehensive assessment of its translational potential in preclinical models are still lacking. Objective: This study seeks to synthesize evidence on the intervention effects and underlying mechanisms of DGSYS in animal models of VaD through a systematic review and meta-analysis, so as to offer preclinical evidence to inform future research. Methods: A comprehensive literature search was performed across eight databases: China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, Wanfang Data, SinoMed, Web of Science, Cochrane Library, PubMed, and EMBASE, to identify studies published from the inception to May 2025 on the effects of DGSYS in animal models of VaD. The primary outcomes were cognitive and behavioral assessments, histopathological alterations in brain tissue, and biomarkers of oxidative stress. The quality of the included studies was assessed using a 10-item checklist, and meta-analysis was conducted with RevMan 5.4 software. Results: Seven studies involving 420 rats and mice were included. DGSYS notably enhanced cognitive and behavioral performance in the animal models. Specifically, DGSYS significantly improved spatial learning and memory performance, as assessed by the Morris water maze, and attenuated oxidative stress-related pathological changes. Conclusion: Current animal studies provide evidence for the multidimensional neuroprotective effects of DGSYS in VaD, with potential mechanisms involving antioxidative stress, inhibition of neuroinflammation, and enhancement of cerebral microcirculation. However, substantial heterogeneity across outcome measures and generally low methodological quality were observed. Overall, the available evidence suggests potential neuroprotective effects of DGSYS in preclinical models, warranting further standardized and rigorously designed studies before clinical translation can be considered. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251058443, identifier CRD420251058443.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.