ArticleEuropean heart journal. Case reports2026
Acute myocardial infarction and cardiac arrest induced by oxymetazoline nasal spray overdose: a case report.
Article in European heart journal. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Spontaneous ST-Segment Elevation in Right Precordial Leads Following Cardiac Arrest: Literature Review and Management Proposal for Ruling out Brugada Syndrome.Cardiovascular drugs and therapy · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oxymetazoline nasal spray is a widely used over-the-counter sympathomimetic decongestant. While generally safe at therapeutic doses, overdose can result in systemic vasoconstriction and potentially life-threatening cardiovascular complications. Case summary: We report the case of a previously healthy 27-year-old man who presented after an out-of-hospital cardiac arrest following excessive use of oxymetazoline nasal spray. He was found in ventricular fibrillation and required cardiopulmonary resuscitation and defibrillation. Post-resuscitation electrocardiogram showed transient ST-segment elevations, and cardiac biomarkers were markedly elevated. However, emergent coronary angiography revealed normal coronary arteries. Comprehensive cardiac evaluation, including cardiac magnetic resonance imaging and electrophysiologic studies, excluded myocardial infarction, myocarditis, myocardial fibrosis, and Brugada syndrome. The patient experienced prolonged neurological recovery but improved with rehabilitation. Discussion: Oxymetazoline overdose should be considered a potential cause of acute coronary syndrome, malignant arrhythmias, and cardiac arrest, even in young individuals without pre-existing cardiovascular disease. Clinician awareness and patient education on the safe use of sympathomimetic agents are essential for prevention.
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