Evidence map›Paper›PMID 41907896›Full record

ArticleBioinformation2025

Novel herbal-antioxidant topical gel for managing chemotherapy-induced oral mucositis in oral cancer patients: A randomized controlled trial.

Sushil Kumar Sahoo, Pulin Saluja, Ashutosh Panda, Disha Makwani, Manish Kumar Chandraker, Shantala R Naik

Abstract read
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sushil Kumar SahooDepartment of Oral and Maxillofacial Surgery, Hi-Tech Dental College and Hospital Bhubaneswar, Odisha, India.
Pulin SalujaDepartment of Oral Pathology, Faculty of Dental Sciences, SGT University, Gurugram, India.
Ashutosh PandaDepartment of Oral and Maxillofacial Surgery, Hi-Tech Dental College and Hospital Bhubaneswar, Odisha, India.
Disha MakwaniDepartment of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Gandhinagar, Ahmedabad, Gujarat, India.
Manish Kumar ChandrakerDepartment of Oral and Maxillofacial Surgery, Maitri College of Dentistry and Research Centre, Durg, Chhattisgarh, India.
Shantala R NaikDepartment of Oral Medicine and Radiology, Dental Institute Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mucositis is a side effect of oral cancer chemotherapy, which is painful and frequent, usually interfering with the continuity and quality of life. This was a randomized controlled trial of a topical gel comprising of novel herbal-antioxidants when compared to standard benzydamine mouthwash in 60 subjects. WHO and VAS scales were used to evaluate the severity of the mucositis and its pain in 21 days. The novel gel exhibited much less decrease in the degree of mucositis (1.2 ± 0.4 vs 2.6 ± 0.6; p < 0.001) and pain levels (2.1 ± 0.9 vs 4.8 ± 1.3) and quicker recovery of the mucosal wound and no side effects. The new topical agent was more used to reduce the severity and duration of oral mucositis, benefiting the patients and enhancing their recovery.

Indexed as

antioxidant gelchemotherapymucosal healingoral cancerOral mucositispain alleviationtopical agent

Identifiers

PMID41907896
PMCPMC13018341

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.