Impact of thyroid autoantibodies on pregnancy: A prospective cohort study.

Yashika Sheetal, Mallikarjun Samala, Rahul Tiwari, Heena Dixit, Anil Managutti, Deepak Sharma, Akriti Mahajan

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Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Yashika SheetalDepartment of Obstetrics and Gynaecology, Saraswati Medical College, Atal Bihari Vajpayee Medical University, Unnao, Lucknow, Uttar Pradesh, India.

Mallikarjun SamalaPiedmont Rockdale Hospital & Family, First Primary Clinic, Atlanta, GA, USA.

Rahul TiwariDepartment of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.

Heena DixitDepartment of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India.

Anil ManaguttiDepartment of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.

Deepak SharmaDepartment of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India.

Akriti MahajanDepartment of Oral medicine and radiology, Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a prospective cohort study of 1,200 pregnant women recruited in early first trimester to evaluate the impact of thyroid autoantibodies (TPOAb and/or TGAb) on maternal and neonatal outcomes. Overall, 18.2% were antibody-positive. Compared with antibody-negative women, those with thyroid autoimmunity had significantly higher risks of pregnancy-induced hypertension (12.6% vs 7.9%), gestational diabetes (15.3% vs 10.2%) and neonatal intensive care unit admission (11.2% vs 6.5%). Adjusted logistic regression confirmed independent associations after controlling for maternal age, BMI, parity and TSH levels. Neonates born to antibody-positive mothers had lower mean birth weight (2980 ± 420 g vs 3125 ± 395 g, p=0.02) and higher risk of small-for-gestational age (8.7% vs 4.9%). Thus, we show that thyroid autoantibodies, even in euthyroid women, are associated with adverse pregnancy outcomes and justify closer monitoring during antenatal care.

Indexed as

gestational diabetes mellitusneonatal intensive care unitspregnancy complicationspregnancy-induced hypertensionThyroid autoantibodies

Identifiers

PMID41907906

DOI10.6026/973206300214749

PMCPMC13018334

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