ArticleFrontiers in cardiovascular medicine2026
Comprehensive lnc-RNAs expression profiles in uremic cardiomyopathy before and after renal transplantation.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic kidney disease (CKD) significantly contributes to increased cardiovascular morbidity and mortality. CKD-induced cardiac remodeling, clinically termed uremic cardiomyopathy (UCM), manifests as morphological and physiological alterations in the myocardium. While renal transplantation is known to mitigate uremia's effects on myocardial remodeling, improve cardiac function, and reverse damage, its underlying biological mechanism remains unclear. Exosomes mediate inter-organ communication, with their nucleic acid components serving as key regulatory molecules. Emerging evidence indicates long non-coding RNAs (lncRNAs) critically participate in cardiac disease mechanisms. Objective: This study aimed to analyze the expression profile of blood exosome-derived lncRNAs in UCM patients before and after transplantation to explore lncRNA expression patterns, regulatory mechanisms, and identify key lncRNAs involved in UCM pathogenesis. Patients and methods: Our study utilized high-throughput RNA sequencing to identify differentially expressed long non-coding RNAs (lncRNAs) in patients with uremic cardiomyopathy (UCM) before and after kidney transplantation. We analyzed the differential expression of lncRNAs from multiple perspectives, including expression profiles, lncRNA-mRNA interaction networks, and enriched GO and KEGG pathways, followed by validation through RT-qPCR. Results: Gene sequencing revealed 769 dysregulated lncRNAs [440 downregulated, 329 upregulated; log2(fold change) > 2.0, Conclusion: LncRNAs show significant correlation with UCM progression before and after renal transplantation. Lnc-LINC02194 may represent a candidate therapeutic target for UCM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.