ReviewNeuropsychiatric disease and treatment2026
A Narrative Review on Rodent Models of Neuropsychopathology Associated with Low Temperature Exposure.
Review in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Oxidative Stress in Animals: A Systematic Analysis from Signaling Pathways to Biological Effects.Life (Basel, Switzerland) · 2026Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present review aims to critically analyse the employment of rodent models for the study of neuropsychopathology associated with low temperature exposure, a semi-manageable environmental stressor. The comprehensive array of data obtained from the animal studies focusing on cold stress-induced dysfunctions in pathophysiological pathways/effectors, including hypothalamo-pituitary-adrenal (HPA axis), neurogenic cascades, synaptic, bioenergetic, metabolic, redox, and immune functions, are extensively delineated in the current review. Our observation based upon findings obtained from previously published studies indicates that in spite of the discrepancies in the manifestation of the low temperature exposure protocols, rodents have been instrumental in discerning prominent cellular and molecular mediators of the adverse changes in neuronal functions and psycho-cognitive dysfunctions associated with cold stress injury. While the data emphasizes a robust and intricate interaction between cold stress, neuronal resilience, and complex brain functions, further research is needed to identify molecular and cellular targets to mitigate the pathophysiological effects of cold stress. Lastly, we also explored the potential of medicinal plants as phytotherapeutic interventions for stimulating brain recovery mechanisms and neutralizing cold stress-induced neurobehavioural deficits. Based on the available evidence, we propose naturopathic approaches employing phytotherapeutic agents as multimodal, safe, and feasible alternatives and complementary strategies for alleviating the adverse effects of cold stress on the brain and behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.