ArticleKidney medicine2026
Renin-Independent Aldosteronism Heightened the Risk of Renal Impairment in Chinese Adults From Hakka Biobank.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rationale & Objective: The differential impact of renin-independent aldosteronism versus renin-dependent aldosteronism on kidney function-particularly urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and their combination-remains unclear in the Chinese Hakka population. This study aimed to compare their associations with renal impairment. Study Design: Cross-sectional analysis. Setting & Participants: A total of 7,760 adults from the Hakka Biobank in Bobai County, Guangxi, China. Exposures: Aldosteronism phenotypes (renin-independent aldosteronism, renin-dependent aldosteronism, and control) defined by plasma aldosterone concentration and plasma renin concentration. Outcomes: Chronic kidney disease (CKD)-UACR (UACR ≥ 3 mg/mmol), CKD-eGFR (eGFR < 60 mL/min/ 1.73 m Analytical Approach: Multivariable logistic and linear regression, restricted cubic splines, and stratified analysis. Results: Renin-independent aldosteronism was associated with higher CKD-combination risk than renin-dependent aldosteronism (OR, 1.21; 95% CI, 1.02-1.45; Limitations: Cross-sectional design precludes causal inference; findings are specific to the Hakka population. Conclusions: Renin-independent aldosteronism confers a higher risk of renal impairment than renin-dependent aldosteronism in the Chinese Hakka population, highlighting the need for early screening and targeted intervention in renin-independent aldosteronism.
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