ArticleJournal of biomedical optics2026
Dual-resolution megahertz optical coherence tomography prototype rectoscope for enhanced visualization of colorectal microstructures.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
17 authors.
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Abstract
Significance: Endoscopic optical coherence tomography (OCT) is a valuable tool for rectal imaging, enabling noninvasive visualization of transmural structures with near-histological resolution, critical for accurate tumor staging and diagnostic/therapeutic monitoring. However, anatomical variability of the rectum and the resulting changes in tissue-to-probe distance challenge optimal circumferential imaging. Aim: We aim to develop a dual-mode endoscopic OCT system, enabling real-time switching between high-detail and extended-range imaging for improved assessment of rectal wall morphology under varying anatomical conditions. Approach: A single fiber-optic ferrule containing two fibers with differing mode fields was integrated into a MHz-OCT rectoscope, enabling an extended-range mode for full circumferential imaging and a high-detail mode for close examination of fine structures with seamless live switching mechanism. The system was tested Results: Postmortem rectum imaging demonstrated the feasibility of real-time switching between the two modes. Extended-range imaging provided full circumferential coverage, whereas high-detail imaging revealed distinct rectal wall layers and fine transmural structures, validated by histological correlation. Conclusions: The dual-mode MHz-OCT system offers a flexible and practical solution for adaptive rectal imaging, providing high-resolution detail and full circumferential coverage with the potential to enhance diagnostics and treatment monitoring.
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