Evidence map›Paper›PMID 41908813›Full record

ArticleFrontiers in pharmacology2026

Xiao Chai Hu Tang-derived decoction (Tung-Yi Fang) suppresses triple negative breast cancer cells

Li-Lan Liao, Zhi-Hu Lin, Chia-Ching Liaw, Hsin Yeh, Wei-Hao Wang, Yun-Chih Chen, Yi-An Lin, Ai-Jung Tseng, Yu-Chun Lin, Wen-Hsin Tsai and 4 more

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In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Li-Lan LiaoInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Zhi-Hu LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chia-Ching LiawSchool of Chinese Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Hsin YehInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wei-Hao WangInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yun-Chih ChenInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-An LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ai-Jung TsengInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yu-Chun LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wen-Hsin TsaiBranch of Linsen Chinese and Kunming, Taipei City Hospital, Taipei, Taiwan.
Chi-Hong ChaoDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Mei-Kuang LuInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chung-Hua HsuInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tung-Yi LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. Xiao Chai Hu Tang (XCHT), a classical herbal formula, is prescribed as an adjuvant therapy in breast cancer care. However, the high sugar content of XCHT may influence its anticancer efficacy under modern experimental conditions. This study investigated the anti-TNBC effects of Tung-Yi Fang (TYF), a sugar-reduced XCHT-derived decoction, and elucidated its underlying mechanisms Methods: TYF was chemically characterized by reverse-phase high-performance liquid chromatography. Its bioactivities were evaluated in TNBC cells using viability and colony formation assays, as well as migration/invasion, cell cycle, and apoptosis analyses. Mechanistic insights were investigated using receptor tyrosine kinase (RTK) arrays, Western blotting, and immunofluorescence analyses. The Results: TYF selectively suppressed TNBC cell growth while exerting minimal effects on non-tumorigenic breast epithelial cells and fibroblasts. TYF induced G2/M cell cycle arrest and apoptotic responses. TYF impaired TNBC cell mobility through disruption of actin cytoskeletal organization and suppression of FAK/Src signaling. RTK profiling and downstream analyses revealed that TYF concurrently regulated EGFR- and AXL-associated signaling pathways, leading to attenuation of AKT, ERK, and STAT3 activation. TYF administration significantly reduced tumor growth and metastatic burden without detectable systemic toxicity Conclusion: TYF exhibits anti-TNBC activity through EGFR and AXL inhibition and suppression of metastatic potential. Its efficacy highlights the therapeutic potential of glucose-controlled herbal formulations in cancer management.

Indexed as

anti-cancerherbal formulatriple-negative breast cancertyrosine kinase receptorXCHT-derived Tung-Yi Fang

Identifiers

PMID41908813
PMCPMC13021619

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.