ReviewNature and science of sleep2026
Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms.
Review in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repeated episodes of complete (apnea) or partial (hypopnea) collapse of the upper airway during sleep, leading to chronic intermittent hypoxia and/or hypercapnia, and sleep fragmentation. This review systematically examines the mechanisms linking OSAS and ischemic stroke, with particular emphasis on the roles of the PI3K/Akt signaling pathway, Toll-like receptor signaling pathway, and NLRP3 inflammasome in OSAS-related inflammatory responses, and their contributions to the pathogenesis and progression of ischemic stroke. We also explore how OSAS affects stroke recovery through impaired sleep quality and increased cardiovascular stress, potentially worsening prognosis. This article discusses potential anti-inflammatory therapeutic strategies, underscores the importance of early OSAS intervention in reducing recurrence and improving outcomes, and offers new perspectives on OSAS-related ischemic stroke mechanisms and clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.