Evidence map›Paper›PMID 41908985›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2026

Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus.

Subhankar Chatterjee, Samya Sengupta, Ritwik Ghosh, Julián Benito-León, Souvik Dubey

Abstract readCase Reports
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Subhankar ChatterjeeDepartment of Endocrinology & Metabolism, Medical College & Hospital, Kolkata, India.ORCID 0000-0002-3555-4412
Samya SenguptaDepartment of Neuromedicine, Bangur Institute of Neurosciences, IPGMER & SSKM Hospital, Kolkata, India.
Ritwik GhoshDepartment of General Medicine, Burdwan Medical College & Hospital, Burdwan, India.ORCID 0000-0002-8192-0807
Julián Benito-LeónDepartment of Neurology, 12 de Octubre University Hospital, Madrid, Spain.ORCID 0000-0002-1769-4809
Souvik DubeyDepartment of Neuromedicine, Bangur Institute of Neurosciences, IPGMER & SSKM Hospital, Kolkata, India.ORCID 0000-0003-1733-3429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hyperglycemia-related movement disorders classically present as hemichorea-hemiballismus, whereas dystonia is far less common and may occasionally precede the recognition of diabetes mellitus. Case Report: A 72-year-old man presented with a 3-month history of recurrent, stereotyped dystonic spells involving the right side of the face, arm, and leg. These episodes occurred approximately twice per minute and lasted about 5 seconds each. Initial laboratory testing revealed a plasma glucose level of 494 mg/dL and an HbA1c of 16.1%, consistent with previously unrecognized diabetes mellitus. Electrolyte levels, electroencephalography, cerebrospinal fluid analysis, and evaluation for autoimmune encephalopathy were unremarkable. Brain MRI showed only a chronic lacunar infarct in the left basal ganglia, with no evidence of an acute striatal lesion. The abnormal movements resolved completely within 3 days after correction of hyperglycemia. Follow-up 18F-FDG PET/CT performed after clinical recovery demonstrated subtle relative hypometabolism in the left cerebellum, with preserved uptake in the basal ganglia and cerebral cortex. Discussion: This case broadens the phenomenologic spectrum of hyperglycemia-related movement disorders and highlights paroxysmal hemidystonia as a potential presenting manifestation of previously undiagnosed diabetes mellitus. Bedside glucose testing should therefore be routinely performed in the evaluation of new-onset paroxysmal hyperkinetic movements. In addition, isolated extra-striatal metabolic abnormalities detected after symptom resolution should be interpreted with caution.

Indexed as

Diabetes MellitusDystonic DisordersHyperglycemiaAgedHumansMalePositron Emission Tomography Computed Tomography18F-FDG PET/CTdiabetes mellitusdiabetic striatopathyhyperglycemiaparoxysmal hemidystonia

Identifiers

PMID41908985
PMCPMC13025155

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.