ArticleFrontiers in nutrition2026
One-month early time-restricted eating enhances cognition via white matter-cortical pathways in males with metabolic syndrome: evidence from TBSS and SBM analyses.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Metabolic syndrome (MetS) is associated with white and gray matter structural abnormalities and cognitive decline, particularly in executive function and memory. Early time-restricted eating (eTRE) is a promising lifestyle intervention to improve metabolic and cognitive health, yet its effects on brain structure remain unclear. Objective: To investigate whether a 1-month eTRE intervention improves metabolic health, brain structure, and cognition in male MetS patients. Methods: Twenty-one males with MetS underwent a 1-month eTRE intervention. Diffusion tensor imaging (DTI), T1-weighted images, metabolic and cognitive measures including the Trail Making Test (TMT), Processing Speed (PS), and Rey Auditory Verbal Learning Test (RAVLT) were collected at baseline and post-intervention. White matter microstructure was analyzed using tract-based spatial statistics (TBSS), and cortical morphology was assessed using surface-based morphometry (SBM). Mediation analysis explored links between cognitive and structural changes. Results: After 1-month eTRE, body weight, BMI, fasting glucose, fasting insulin, and HOMA-IR significantly decreased, while QUICKI increased (all Conclusion: One month of eTRE was associated with metabolic improvement and coordinated changes in brain structure and cognition in males with MetS, consistent with adaptive thalamo-prefrontal network remodeling.
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